null
SMILES: COc1ccc(OC)c2CN3CCc4cc5OCOc5cc4[C@@H]3Cc12
InChI Key: InChIKey=OIKSHMCSVZMXCU-INIZCTEOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM235777 (US9359372, DC037013 | US9359372, DC037034) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 23.6 | -10.6 | 47.9 | n/a | n/a | n/a | n/a | n/a | 30 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM235777 (US9359372, DC037013 | US9359372, DC037034) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 23.6 | -10.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were s... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM235777 (US9359372, DC037013 | US9359372, DC037034) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 248 | -9.16 | 484 | n/a | n/a | n/a | n/a | n/a | 30 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM235777 (US9359372, DC037013 | US9359372, DC037034) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 485 | -8.75 | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | 30 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM235777 (US9359372, DC037013 | US9359372, DC037034) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 497 | -8.74 | 631 | n/a | n/a | n/a | n/a | n/a | 30 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM235777 (US9359372, DC037013 | US9359372, DC037034) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 9.74E+3 | n/a | n/a | n/a | 37 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent | Assay Description Each medicament was dissolved in serum-free F12 culture medium containing 100 μM of IBMX. CHO cells which can stably express D2 receptor were pre-... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair |