BDBM235962 US9365546, 285
SMILES: Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)C
InChI Key: InChIKey=RAVOJDKMDLUTLW-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human)) | BDBM235962 (US9365546, 285) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.5 | 25 |
CONFLUENCE LIFE SCIENCES INC. US Patent | Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,... | US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human)) | BDBM235962 (US9365546, 285) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.5 | 25 |
CONFLUENCE LIFE SCIENCES INC. US Patent | Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,... | US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human)) | BDBM235962 (US9365546, 285) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 121 | n/a | n/a | n/a | n/a | 7.5 | 25 |
CONFLUENCE LIFE SCIENCES INC. US Patent | Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,... | US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human)) | BDBM235962 (US9365546, 285) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | 7.5 | 25 |
CONFLUENCE LIFE SCIENCES INC. US Patent | Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,... | US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP | |||||||||||
More data for this Ligand-Target Pair |