BDBM236248 US9365576, 1

SMILES: COc1ccccc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F

InChI Key: InChIKey=HPUAUMBBZXSYGE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 236248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM4 (Homo sapiens (Human))	BDBM236248 (US9365576, 1) Show SMILES COc1ccccc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F Show InChI InChI=1S/C29H25Cl2FN2O2/c1-16(2)33-24(20-8-5-6-11-25(20)36-4)15-21-28(33)27(19-13-12-18(30)14-17(19)3)34(29(21)35)23-10-7-9-22(31)26(23)32/h5-16,27H,1-4H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.78E+4	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM2 (Homo sapiens (Human))	BDBM236248 (US9365576, 1) Show SMILES COc1ccccc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F Show InChI InChI=1S/C29H25Cl2FN2O2/c1-16(2)33-24(20-8-5-6-11-25(20)36-4)15-21-28(33)27(19-13-12-18(30)14-17(19)3)34(29(21)35)23-10-7-9-22(31)26(23)32/h5-16,27H,1-4H3	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair