BDBM236336 US9365576, 89

SMILES: COc1ccc(cc1-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(O)=O

InChI Key: InChIKey=ILWFBBGNMHVGNM-MHZLTWQESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 236336   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM236336 (US9365576, 89) Show SMILES COc1ccc(cc1-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(O)=O |r| Show InChI InChI=1S/C30H26Cl2N2O4/c1-16(2)33-25(22-13-19(30(36)37)8-12-26(22)38-4)15-23-28(33)27(18-6-10-20(31)11-7-18)34(29(23)35)24-14-21(32)9-5-17(24)3/h5-16,27H,1-4H3,(H,36,37)/t27-/m0/s1	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair