Found 3 hits for monomerid = 236350 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
p53-MDM2
(Homo sapiens (Human)) | BDBM236350
(US9365576, 103)Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2C)[C@H]2CC[C@H](O)CC2)c(OC)n1 |r,wU:29.32,wD:26.28,(8.91,.26,;8.14,1.6,;6.6,1.6,;5.83,.26,;4.29,.26,;3.52,1.6,;1.98,1.6,;1.08,2.84,;-.38,2.37,;-1.85,2.84,;-2.62,4.18,;-2.75,1.6,;-1.85,.35,;-.38,.83,;1.08,.35,;1.48,-1.14,;.39,-2.22,;2.97,-1.53,;-2.25,-1.14,;-1.16,-2.22,;-1.56,-3.71,;-3.05,-4.11,;-3.44,-5.6,;-4.13,-3.02,;-3.74,-1.53,;-4.82,-.45,;-4.29,1.6,;-5.06,2.93,;-6.6,2.93,;-7.37,1.6,;-8.91,1.6,;-6.6,.26,;-5.06,.26,;4.29,2.93,;3.52,4.26,;4.29,5.6,;5.83,2.93,)| Show InChI InChI=1S/C28H33ClN4O4/c1-15(2)32-23(22-14-30-28(37-5)31-26(22)36-4)13-21-25(32)24(20-11-6-17(29)12-16(20)3)33(27(21)35)18-7-9-19(34)10-8-18/h6,11-15,18-19,24,34H,7-10H2,1-5H3/t18-,19-,24? | PDB
MMDB
Reactome pathway
KEGG
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20.7 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... |
US Patent US9365576 (2016)
BindingDB Entry DOI: 10.7270/Q2DN43XR |
More data for this
Ligand-Target Pair | |
p53-MDM2
(Homo sapiens (Human)) | BDBM236350
(US9365576, 103)Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2C)[C@H]2CC[C@H](O)CC2)c(OC)n1 |r,wU:29.32,wD:26.28,(8.91,.26,;8.14,1.6,;6.6,1.6,;5.83,.26,;4.29,.26,;3.52,1.6,;1.98,1.6,;1.08,2.84,;-.38,2.37,;-1.85,2.84,;-2.62,4.18,;-2.75,1.6,;-1.85,.35,;-.38,.83,;1.08,.35,;1.48,-1.14,;.39,-2.22,;2.97,-1.53,;-2.25,-1.14,;-1.16,-2.22,;-1.56,-3.71,;-3.05,-4.11,;-3.44,-5.6,;-4.13,-3.02,;-3.74,-1.53,;-4.82,-.45,;-4.29,1.6,;-5.06,2.93,;-6.6,2.93,;-7.37,1.6,;-8.91,1.6,;-6.6,.26,;-5.06,.26,;4.29,2.93,;3.52,4.26,;4.29,5.6,;5.83,2.93,)| Show InChI InChI=1S/C28H33ClN4O4/c1-15(2)32-23(22-14-30-28(37-5)31-26(22)36-4)13-21-25(32)24(20-11-6-17(29)12-16(20)3)33(27(21)35)18-7-9-19(34)10-8-18/h6,11-15,18-19,24,34H,7-10H2,1-5H3/t18-,19-,24? | PDB
MMDB
Reactome pathway
KEGG
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 30.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... |
US Patent US9365576 (2016)
BindingDB Entry DOI: 10.7270/Q2DN43XR |
More data for this
Ligand-Target Pair | |
p53-MDM4
(Homo sapiens (Human)) | BDBM236350
(US9365576, 103)Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2C)[C@H]2CC[C@H](O)CC2)c(OC)n1 |r,wU:29.32,wD:26.28,(8.91,.26,;8.14,1.6,;6.6,1.6,;5.83,.26,;4.29,.26,;3.52,1.6,;1.98,1.6,;1.08,2.84,;-.38,2.37,;-1.85,2.84,;-2.62,4.18,;-2.75,1.6,;-1.85,.35,;-.38,.83,;1.08,.35,;1.48,-1.14,;.39,-2.22,;2.97,-1.53,;-2.25,-1.14,;-1.16,-2.22,;-1.56,-3.71,;-3.05,-4.11,;-3.44,-5.6,;-4.13,-3.02,;-3.74,-1.53,;-4.82,-.45,;-4.29,1.6,;-5.06,2.93,;-6.6,2.93,;-7.37,1.6,;-8.91,1.6,;-6.6,.26,;-5.06,.26,;4.29,2.93,;3.52,4.26,;4.29,5.6,;5.83,2.93,)| Show InChI InChI=1S/C28H33ClN4O4/c1-15(2)32-23(22-14-30-28(37-5)31-26(22)36-4)13-21-25(32)24(20-11-6-17(29)12-16(20)3)33(27(21)35)18-7-9-19(34)10-8-18/h6,11-15,18-19,24,34H,7-10H2,1-5H3/t18-,19-,24? | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.71E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... |
US Patent US9365576 (2016)
BindingDB Entry DOI: 10.7270/Q2DN43XR |
More data for this
Ligand-Target Pair | |
Search and Browse
