BDBM236355 US9365576, 108

SMILES: COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)C1CCC(=O)N(C)C1

InChI Key: InChIKey=BKRCNHSWDZEYIT-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 236355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM236355 (US9365576, 108) Show SMILES COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)C1CCC(=O)N(C)C1 Show InChI InChI=1S/C26H29ClN6O3/c1-14(2)32-20(19-12-29-26(28)30-24(19)36-4)11-18-23(32)22(15-5-7-16(27)8-6-15)33(25(18)35)17-9-10-21(34)31(3)13-17/h5-8,11-12,14,17,22H,9-10,13H2,1-4H3,(H2,28,29,30)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM2 (Homo sapiens (Human))	BDBM236355 (US9365576, 108) Show SMILES COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)C1CCC(=O)N(C)C1 Show InChI InChI=1S/C26H29ClN6O3/c1-14(2)32-20(19-12-29-26(28)30-24(19)36-4)11-18-23(32)22(15-5-7-16(27)8-6-15)33(25(18)35)17-9-10-21(34)31(3)13-17/h5-8,11-12,14,17,22H,9-10,13H2,1-4H3,(H2,28,29,30)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM4 (Homo sapiens (Human))	BDBM236355 (US9365576, 108) Show SMILES COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)C1CCC(=O)N(C)C1 Show InChI InChI=1S/C26H29ClN6O3/c1-14(2)32-20(19-12-29-26(28)30-24(19)36-4)11-18-23(32)22(15-5-7-16(27)8-6-15)33(25(18)35)17-9-10-21(34)31(3)13-17/h5-8,11-12,14,17,22H,9-10,13H2,1-4H3,(H2,28,29,30)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.02E+3	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair