BDBM236884 US9388171, II-2
SMILES: CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2c1)c1ccc(Cl)c(F)c1
InChI Key: InChIKey=PQBOEVFVXNDSJY-JOCHJYFZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase alpha 1 (Homo sapiens (Human)) | BDBM236884 (US9388171, II-2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | 37 |
GENETECH, INC.; ARRAY BIOPHARMA INC. US Patent | Assay Description HepG2 cells were obtained from ATCC and grown in DMEM supplemented with 10% fetal bovine serum. Cells were plated in 96-well plates at 35,000 cells/w... | US Patent US9388171 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81SV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human)) | BDBM236884 (US9388171, II-2) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 7.3 | n/a |
GENETECH, INC.; ARRAY BIOPHARMA INC. US Patent | Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro... | US Patent US9388171 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81SV | |||||||||||
More data for this Ligand-Target Pair |