null

SMILES: COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)cc2c1

InChI Key: InChIKey=UXYSSMZFOQFSRB-BJKOFHAPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 236890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM236890 (US9388171, II-64) Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)cc2c1 |r| Show InChI InChI=1S/C27H30N6O2/c1-17-11-26(33(3)31-17)30-25-13-21-12-19(5-6-20(21)14-28-25)27(34)29-24-16-32(2)15-23(24)18-7-9-22(35-4)10-8-18/h5-14,23-24H,15-16H2,1-4H3,(H,28,30)(H,29,34)/t23-,24+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.47	n/a	n/a	n/a	n/a	n/a	37
GENETECH, INC.; ARRAY BIOPHARMA INC. US Patent					Assay Description HepG2 cells were obtained from ATCC and grown in DMEM supplemented with 10% fetal bovine serum. Cells were plated in 96-well plates at 35,000 cells/w...				US Patent US9388171 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81SV
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM236890 (US9388171, II-64) Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)cc2c1 |r| Show InChI InChI=1S/C27H30N6O2/c1-17-11-26(33(3)31-17)30-25-13-21-12-19(5-6-20(21)14-28-25)27(34)29-24-16-32(2)15-23(24)18-7-9-22(35-4)10-8-18/h5-14,23-24H,15-16H2,1-4H3,(H,28,30)(H,29,34)/t23-,24+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.68	n/a	n/a	n/a	n/a	7.3	n/a
GENETECH, INC.; ARRAY BIOPHARMA INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9388171 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81SV
					More data for this Ligand-Target Pair