BDBM237220 1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylthiourea (1b)
SMILES: COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2)ccc1O
InChI Key: InChIKey=GYACEUCFQRKYBI-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Mitogen-activated protein kinase; ERK1/ERK2 (Homo sapiens (Human)) | BDBM237220 (1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylthioure...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University | Assay Description Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv... | J Enzyme Inhib Med Chem 27: 708-14 (2012) Article DOI: 10.3109/14756366.2011.608665 BindingDB Entry DOI: 10.7270/Q2N015FS | |||||||||||
More data for this Ligand-Target Pair |