BDBM237223 1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-phenylthiourea (4b)

SMILES: COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O

InChI Key: InChIKey=VQWDJONNCPSGAK-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 237223   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ETS domain-containing protein (Elk1) (Homo sapiens (Human))	BDBM237223 (1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...) Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University					Assay Description Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...				J Enzyme Inhib Med Chem 27: 708-14 (2012) Article DOI: 10.3109/14756366.2011.608665 BindingDB Entry DOI: 10.7270/Q2N015FS
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1 (Homo sapiens (Human))	BDBM237223 (1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...) Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University					Assay Description Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...				J Enzyme Inhib Med Chem 27: 708-14 (2012) Article DOI: 10.3109/14756366.2011.608665 BindingDB Entry DOI: 10.7270/Q2N015FS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2 (Homo sapiens (Human))	BDBM237223 (1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...) Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University					Assay Description Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...				J Enzyme Inhib Med Chem 27: 708-14 (2012) Article DOI: 10.3109/14756366.2011.608665 BindingDB Entry DOI: 10.7270/Q2N015FS
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2 (Homo sapiens (Human))	BDBM237223 (1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...) Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University					Assay Description Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...				J Enzyme Inhib Med Chem 27: 708-14 (2012) Article DOI: 10.3109/14756366.2011.608665 BindingDB Entry DOI: 10.7270/Q2N015FS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2 (Homo sapiens (Human))	BDBM237223 (1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...) Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University					Assay Description Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...				J Enzyme Inhib Med Chem 27: 708-14 (2012) Article DOI: 10.3109/14756366.2011.608665 BindingDB Entry DOI: 10.7270/Q2N015FS
					More data for this Ligand-Target Pair