BDBM238270 US9409887, I-1
SMILES: COc1cc(NC2CN(CCF)C2)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F
InChI Key: InChIKey=BFSRTTWIPACGMI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF-R Tyrosine Kinase (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (EGFR)(T790M/L858R) (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description A431 human epidermoid carcinoma, H1975 human NSCLC and HCC827 human NSCLC adenocarcinoma cells were obtained from the American Type Culture Center (M... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EGF-R Tyrosine Kinase (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description A431 human epidermoid carcinoma, H1975 human NSCLC and HCC827 human NSCLC adenocarcinoma cells were obtained from the American Type Culture Center (M... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (EGFR)(T790M/L858R) (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair |