BDBM238350 US9388165, 8
SMILES: Cc1ccc(cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12)C(=O)Nc1ccccc1
InChI Key: InChIKey=ZIYOVHCFFWBQJR-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM238350 (US9388165, 8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20.5 | n/a | n/a | n/a | n/a | n/a | n/a |
HANMI PHARM. CO., LTD. US Patent | Assay Description The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B... | US Patent US9388165 (2016) BindingDB Entry DOI: 10.7270/Q2F76BF9 | |||||||||||
More data for this Ligand-Target Pair |