BDBM239064 US10227295, Compound 11a::US9409858, 11a::US9956192, Compound 11a

SMILES: ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1

InChI Key: InChIKey=UOMQYWKOSVYLAQ-HNNXBMFYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 239064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM239064 (US10227295, Compound 11a | US9409858, 11a | US9956...) Show SMILES ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1 |r| Show InChI InChI=1S/C18H17N3O4/c22-16(20-25)14-8-6-13(7-9-14)11-21-17(23)15(19-18(21)24)10-12-4-2-1-3-5-12/h1-9,15,25H,10-11H2,(H,19,24)(H,20,22)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.56E+3	n/a	n/a	n/a	n/a	8.0	n/a
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois US Patent					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				US Patent US9409858 (2016) BindingDB Entry DOI: 10.7270/Q21V5CWN
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM239064 (US10227295, Compound 11a | US9409858, 11a | US9956...) Show SMILES ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1 |r| Show InChI InChI=1S/C18H17N3O4/c22-16(20-25)14-8-6-13(7-9-14)11-21-17(23)15(19-18(21)24)10-12-4-2-1-3-5-12/h1-9,15,25H,10-11H2,(H,19,24)(H,20,22)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.6	n/a	n/a	n/a	n/a	8.0	n/a
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois US Patent					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				US Patent US9409858 (2016) BindingDB Entry DOI: 10.7270/Q21V5CWN
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM239064 (US10227295, Compound 11a | US9409858, 11a | US9956...) Show SMILES ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1 |r| Show InChI InChI=1S/C18H17N3O4/c22-16(20-25)14-8-6-13(7-9-14)11-21-17(23)15(19-18(21)24)10-12-4-2-1-3-5-12/h1-9,15,25H,10-11H2,(H,19,24)(H,20,22)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.6	n/a	n/a	n/a	n/a	n/a	n/a
KuDOS Pharmaceuticals Ltd.					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 6581-91 (2008) BindingDB Entry DOI: 10.7270/Q2BZ68CW
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM239064 (US10227295, Compound 11a | US9409858, 11a | US9956...) Show SMILES ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1 |r| Show InChI InChI=1S/C18H17N3O4/c22-16(20-25)14-8-6-13(7-9-14)11-21-17(23)15(19-18(21)24)10-12-4-2-1-3-5-12/h1-9,15,25H,10-11H2,(H,19,24)(H,20,22)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.6	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 196-218 (2008) BindingDB Entry DOI: 10.7270/Q2VD71RF
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM239064 (US10227295, Compound 11a | US9409858, 11a | US9956...) Show SMILES ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1 |r| Show InChI InChI=1S/C18H17N3O4/c22-16(20-25)14-8-6-13(7-9-14)11-21-17(23)15(19-18(21)24)10-12-4-2-1-3-5-12/h1-9,15,25H,10-11H2,(H,19,24)(H,20,22)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
KuDOS Pharmaceuticals Ltd.					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 6581-91 (2008) BindingDB Entry DOI: 10.7270/Q2BZ68CW
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM239064 (US10227295, Compound 11a | US9409858, 11a | US9956...) Show SMILES ONC(=O)c1ccc(CN2C(=O)N[C@@H](Cc3ccccc3)C2=O)cc1 |r| Show InChI InChI=1S/C18H17N3O4/c22-16(20-25)14-8-6-13(7-9-14)11-21-17(23)15(19-18(21)24)10-12-4-2-1-3-5-12/h1-9,15,25H,10-11H2,(H,19,24)(H,20,22)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...				J Med Chem 51: 196-218 (2008) BindingDB Entry DOI: 10.7270/Q2VD71RF
					More data for this Ligand-Target Pair