BDBM239155 7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-methylcoumarine (1a)
SMILES: Cc1ncc(n1CCOc1ccc2c(C)cc(=O)oc2c1)[N+]([O-])=O
InChI Key: InChIKey=DZSMNKZDRKEEQX-UHFFFAOYSA-N
Data: 11 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 370 | -8.15 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase VB (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 380 | -8.14 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 390 | -8.12 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 7 (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 420 | -8.08 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 460 | -8.03 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase VA (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 840 | -7.70 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase XIV (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 930 | -7.64 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | >2.00E+5 | >-4.69 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | >2.00E+5 | >-4.69 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | >2.00E+5 | >-4.69 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 13 (CA XIII) (Homo sapiens (Human)) | BDBM239155 (7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-me...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | >2.00E+5 | >-4.69 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 28: 397-401 (2013) Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F | |||||||||||
More data for this Ligand-Target Pair |