BDBM24079 3,5-diaryl-4,5-dihydropyrazole, 9d::4-[3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-N,N-dimethylbutanamine oxide
SMILES: CCNC(=O)N1N=C(CC1(CCCC[N+](C)(C)[O-])c1ccccc1)c1cc(F)ccc1F
InChI Key: InChIKey=NWFWLXVUCFLSOQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human)) | BDBM24079 (3,5-diaryl-4,5-dihydropyrazole, 9d | 4-[3-(2,5-dif...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 585 | n/a | n/a | n/a | n/a | 7.0 | 23 |
Merck Research Laboratories | Assay Description The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term... | Bioorg Med Chem Lett 16: 3175-9 (2006) Article DOI: 10.1016/j.bmcl.2006.03.040 BindingDB Entry DOI: 10.7270/Q2445JTH | |||||||||||
More data for this Ligand-Target Pair |