BDBM24082 3,5-diaryl-4,5-dihydropyrazole, 9g::N-{4-[3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl]butyl}-1H-imidazole-2-carboxamide

SMILES: CCNC(=O)N1N=C(CC1(CCCCNC(=O)c1ncc[nH]1)c1ccccc1)c1cc(F)ccc1F

InChI Key: InChIKey=HLLSMWRIVCVNPC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24082   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM24082 (3,5-diaryl-4,5-dihydropyrazole, 9g | N-{4-[3-(2,5-...) Show SMILES CCNC(=O)N1N=C(CC1(CCCCNC(=O)c1ncc[nH]1)c1ccccc1)c1cc(F)ccc1F |c:6| Show InChI InChI=1S/C26H28F2N6O2/c1-2-29-25(36)34-26(18-8-4-3-5-9-18,12-6-7-13-32-24(35)23-30-14-15-31-23)17-22(33-34)20-16-19(27)10-11-21(20)28/h3-5,8-11,14-16H,2,6-7,12-13,17H2,1H3,(H,29,36)(H,30,31)(H,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	552	n/a	n/a	n/a	n/a	7.0	23
Merck Research Laboratories					Assay Description The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...				Bioorg Med Chem Lett 16: 3175-9 (2006) Article DOI: 10.1016/j.bmcl.2006.03.040 BindingDB Entry DOI: 10.7270/Q2445JTH
					More data for this Ligand-Target Pair