BDBM24092 1,4-diaryl-4,5-dihydropyrazole, 12::4-{3-[1-(2,5-difluorophenyl)-3-acetyl-4-phenyl-4,5-dihydro-1H-pyrazol-4-yl]propyl}-1,4-thiomorpholine-1,1-dione::Racemate
SMILES: CC(=O)C1=NN(CC1(CCCN1CCS(=O)(=O)CC1)c1ccccc1)c1cc(F)ccc1F
InChI Key: InChIKey=XTTXOVQPTVWBOC-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human)) | BDBM24092 (1,4-diaryl-4,5-dihydropyrazole, 12 | 4-{3-[1-(2,5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | 7.0 | 23 |
Merck Research Laboratories | Assay Description The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term... | Bioorg Med Chem Lett 17: 5677-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.074 BindingDB Entry DOI: 10.7270/Q20C4T36 | |||||||||||
More data for this Ligand-Target Pair |