Found 3 hits for monomerid = 24127 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Kinesin Spindle Protein Eg5
(Homo sapiens (Human)) | BDBM24127
((4R)-4-(3-hydroxyphenyl)-N,N,7,8-tetramethyl-1,2,3...)Show SMILES CN(C)C(=O)N1C[C@H](c2cccc(O)c2)c2ccc(C)c(C)c2C1 |r| Show InChI InChI=1S/C20H24N2O2/c1-13-8-9-17-18(14(13)2)11-22(20(24)21(3)4)12-19(17)15-6-5-7-16(23)10-15/h5-10,19,23H,11-12H2,1-4H3/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | 7.0 | 23 |
Bristol-Myers Squibb Company
| Assay Description ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega). |
Bioorg Med Chem Lett 16: 2095-100 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.056 BindingDB Entry DOI: 10.7270/Q2VM49KF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Kinesin-like protein 1
(Homo sapiens (Human)) | BDBM24127
((4R)-4-(3-hydroxyphenyl)-N,N,7,8-tetramethyl-1,2,3...)Show SMILES CN(C)C(=O)N1C[C@H](c2cccc(O)c2)c2ccc(C)c(C)c2C1 |r| Show InChI InChI=1S/C20H24N2O2/c1-13-8-9-17-18(14(13)2)11-22(20(24)21(3)4)12-19(17)15-6-5-7-16(23)10-15/h5-10,19,23H,11-12H2,1-4H3/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of KSP |
Bioorg Med Chem Lett 17: 722-6 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.083 BindingDB Entry DOI: 10.7270/Q2HT2Q4S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Kinesin-like protein 1
(Homo sapiens (Human)) | BDBM24127
((4R)-4-(3-hydroxyphenyl)-N,N,7,8-tetramethyl-1,2,3...)Show SMILES CN(C)C(=O)N1C[C@H](c2cccc(O)c2)c2ccc(C)c(C)c2C1 |r| Show InChI InChI=1S/C20H24N2O2/c1-13-8-9-17-18(14(13)2)11-22(20(24)21(3)4)12-19(17)15-6-5-7-16(23)10-15/h5-10,19,23H,11-12H2,1-4H3/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 306 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of KSP |
Bioorg Med Chem Lett 17: 722-6 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.083 BindingDB Entry DOI: 10.7270/Q2HT2Q4S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |