BindingDB PrimarySearch

BDBM24185 (3-aminopropyl)(methyl)phosphinic acid::3-Apmpa::3-aminopropylphosphinic derivative, 2::CGP35024::CHEMBL112710::SKF-97541

SMILES: CP(O)(=O)CCCN

InChI Key: InChIKey=NHVRIDDXGZPJTJ-UHFFFAOYSA-N

Data: 3 KI 4 IC50 2 EC50

PDB links: 2 PDB IDs match this monomer. 10 PDB IDs contain this monomer as substructures. 10 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 24185
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by PDSP K_i Database									Eur J Pharmacol 329: 223-9 (1997) BindingDB Entry DOI: 10.7270/Q2H41PZV
University of Sydney Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
gamma-Aminobutyric Acid Type B Receptor (Rattus norvegicus (rat))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	33	-10.1	n/a	n/a	41	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
AstraZeneca					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA A receptor alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by PDSP K_i Database									Eur J Pharmacol 329: 223-9 (1997) BindingDB Entry DOI: 10.7270/Q2H41PZV
University of Sydney Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Homo sapiens (Human))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of mammalian Gamma-aminobutyric acid type B receptor (potent agonist)				Bioorg Med Chem Lett 6: 2073-2076 (1996) Article DOI: 10.1016/0960-894X(96)00364-2 BindingDB Entry DOI: 10.7270/Q2DV1KC9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG Curated by ChEMBL					Assay Description Inhibition of binding of [3H]-CGP-27,492 to gamma-aminobutyric acid type B receptor of rat cortex.				J Med Chem 38: 3313-31 (1995) BindingDB Entry DOI: 10.7270/Q2HD7TPZ
CIBA-GEIGY AG Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-B receptor 1/2 (Homo sapiens (Human))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG Curated by ChEMBL					Assay Description Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum				J Med Chem 38: 3297-312 (1995) BindingDB Entry DOI: 10.7270/Q2N58KDP
CIBA-GEIGY AG Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro displacement of [3H]-GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes				Bioorg Med Chem Lett 3: 515-518 (1993) Article DOI: 10.1016/S0960-894X(01)81218-X BindingDB Entry DOI: 10.7270/Q2BR8S4N
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid \| 3-Apmpa \|...) Show SMILES CP(O)(=O)CCCN Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG Curated by ChEMBL					Assay Description Inhibition of [3H]-CGP-27,492 binding to Gamma-aminobutyric acid type B receptor of rat cortex				J Med Chem 38: 3297-312 (1995) BindingDB Entry DOI: 10.7270/Q2N58KDP
CIBA-GEIGY AG Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)