null
SMILES: NCC(=O)CP(O)O
InChI Key: InChIKey=WNFWMMXTRVEXDO-UHFFFAOYSA-N
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 50 | -9.85 | n/a | n/a | 130 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 94 | -9.48 | n/a | n/a | 220 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10E+3 | -7.66 | n/a | n/a | 1.10E+3 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid type B receptor subunit 1/2 (Homo sapiens (Human)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY AG Curated by ChEMBL | Assay Description Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum | J Med Chem 38: 3297-312 (1995) BindingDB Entry DOI: 10.7270/Q2N58KDP | |||||||||||
More data for this Ligand-Target Pair |