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BDBM2419 1-{2-[(4-tert-butylphenyl)(phenyl)methoxy]ethyl}-2-methyl-5-nitro-1H-imidazole::Diarylmethoxyethylmethylnitroimidazole (DAMNI) 6f

SMILES: Cc1ncc(n1CCOC(c1ccccc1)c1ccc(cc1)C(C)(C)C)[N+]([O-])=O

InChI Key: InChIKey=XADPOCNZKTWWIK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2419   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)		BDBM2419
PNG
(1-{2-[(4-tert-butylphenyl)(phenyl)methoxy]ethyl}-2...)
Show SMILES Cc1ncc(n1CCOC(c1ccccc1)c1ccc(cc1)C(C)(C)C)[N+]([O-])=O
Show InChI InChI=1S/C23H27N3O3/c1-17-24-16-21(26(27)28)25(17)14-15-29-22(18-8-6-5-7-9-18)19-10-12-20(13-11-19)23(2,3)4/h5-13,16,22H,14-15H2,1-4H3
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PC cid
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UniChem

Similars
Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Universita degli Studi di Roma La Sapienza



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

Bioorg Med Chem Lett 10: 253-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00664-2
BindingDB Entry DOI: 10.7270/Q2Q81B7J
More data for this
Ligand-Target Pair