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BDBM2421 1-{2-[(2,4-dichlorophenyl)(phenyl)methoxy]ethyl}-2-methyl-5-nitro-1H-imidazole::Diarylmethoxyethylmethylnitroimidazole (DAMNI) 6j

SMILES: Cc1ncc(n1CCOC(c1ccccc1)c1ccc(Cl)cc1Cl)[N+]([O-])=O

InChI Key: InChIKey=YIAXSBNLNLHQBR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2421   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)		BDBM2421
PNG
(1-{2-[(2,4-dichlorophenyl)(phenyl)methoxy]ethyl}-2...)
Show SMILES Cc1ncc(n1CCOC(c1ccccc1)c1ccc(Cl)cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C19H17Cl2N3O3/c1-13-22-12-18(24(25)26)23(13)9-10-27-19(14-5-3-2-4-6-14)16-8-7-15(20)11-17(16)21/h2-8,11-12,19H,9-10H2,1H3
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Similars
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Universita degli Studi di Roma La Sapienza



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

Bioorg Med Chem Lett 10: 253-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00664-2
BindingDB Entry DOI: 10.7270/Q2Q81B7J
More data for this
Ligand-Target Pair