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BDBM243056 PTP inhibitor, 4h

SMILES: Oc1cc(O)c2C(=O)CC(Oc2c1)c1ccccc1Br

InChI Key: InChIKey=GLXDKPDWZJWNPP-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243056   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM243056
PNG
(PTP inhibitor, 4h)
Show SMILES Oc1cc(O)c2C(=O)CC(Oc2c1)c1ccccc1Br
Show InChI InChI=1/C15H11BrO4/c16-10-4-2-1-3-9(10)13-7-12(19)15-11(18)5-8(17)6-14(15)20-13/h1-6,13,17-18H,7H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.90E+3n/an/an/an/a6.530



Yanbian University College of Pharmacy



Assay Description
Briefly, the enzymatic activity of the PTP1B catalytic domain was determinedat 30C by monitoring the hydrolysis of pNPP. Dephosphorylation of pNPP g...


J Enzyme Inhib Med Chem 28: 1199-204 (2013)


Article DOI: 10.3109/14756366.2012.723206
BindingDB Entry DOI: 10.7270/Q2668C3G
More data for this
Ligand-Target Pair