BDBM243062 PTP inhibitor, 4n
SMILES: COc1ccc(cc1)C1CC(=O)c2c(O)cc(O)cc2O1
InChI Key: InChIKey=HMUJXQRRKBLVOO-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM243062![]() (PTP inhibitor, 4n) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.31E+4 | n/a | n/a | n/a | n/a | 6.5 | 30 |
Yanbian University College of Pharmacy | Assay Description Briefly, the enzymatic activity of the PTP1B catalytic domain was determinedat 30°C by monitoring the hydrolysis of pNPP. Dephosphorylation of pNPP g... | J Enzyme Inhib Med Chem 28: 1199-204 (2013) Article DOI: 10.3109/14756366.2012.723206 BindingDB Entry DOI: 10.7270/Q2668C3G | |||||||||||
More data for this Ligand-Target Pair |