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SMILES: Cc1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1

InChI Key: InChIKey=CAECQSYTSKEWOC-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243345   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM243345
PNG
(4-{5-[3-(4-Methyl- pyrimidin-2-ylamino)- phenyl]-o...)
Show SMILES Cc1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1
Show InChI InChI=1S/C20H20N6O2/c1-13-5-8-22-18(24-13)25-15-4-2-3-14(11-15)16-12-23-19(28-16)26-10-9-21-17(27)20(26)6-7-20/h2-5,8,11-12H,6-7,9-10H2,1H3,(H,21,27)(H,22,24,25)
PDB
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KEGG

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PC cid
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US Patent
n/an/a<500n/an/an/an/a7.825



AB SCIENCE

US Patent


Assay Description
SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...

US Patent US10053455 (2018)


BindingDB Entry DOI: 10.7270/Q27946PV
More data for this
Ligand-Target Pair