BDBM243347 4-{5-[3-Morpholin-4- ylmethy1-5-(4- trifluoromethyl-pyrimidin- 2-ylamino)-phenyl]- oxazol-2-yl}-4,7-diaza- spiro[2.5]octan-8-one::US10053455, 003

SMILES: FC(F)(F)c1ccnc(Nc2cc(CN3CCOCC3)cc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1

InChI Key: InChIKey=XMAXUMVOUHBAHS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243347   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243347 (4-{5-[3-Morpholin-4- ylmethy1-5-(4- trifluoromethy...) Show SMILES FC(F)(F)c1ccnc(Nc2cc(CN3CCOCC3)cc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1 Show InChI InChI=1S/C25H26F3N7O3/c26-25(27,28)20-1-4-30-22(33-20)32-18-12-16(15-34-7-9-37-10-8-34)11-17(13-18)19-14-31-23(38-19)35-6-5-29-21(36)24(35)2-3-24/h1,4,11-14H,2-3,5-10,15H2,(H,29,36)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
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