BDBM243352 4-{5-[3-(4- Trifluoromethyl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-4,7- diaza-spiro[2.5]octan-8- one::US10053455, 008

SMILES: FC(F)(F)c1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1

InChI Key: InChIKey=BJSFXNCBGOPCCB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243352 (4-{5-[3-(4- Trifluoromethyl- pyrimidin-2-ylamino)-...) Show SMILES FC(F)(F)c1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1 Show InChI InChI=1S/C20H17F3N6O2/c21-20(22,23)15-4-7-25-17(28-15)27-13-3-1-2-12(10-13)14-11-26-18(31-14)29-9-8-24-16(30)19(29)5-6-19/h1-4,7,10-11H,5-6,8-9H2,(H,24,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
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