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SMILES: O=C1NCCN(c2ncc(o2)-c2cccc(Nc3nccc(n3)-c3ccccc3)c2)C11CC1

InChI Key: InChIKey=WJQNGZJQWVTNLJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243354   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM243354
PNG
(4-{5-[3-(4-Phenyl- pyrimidin-2-ylamino)- phenyl]-o...)
Show SMILES O=C1NCCN(c2ncc(o2)-c2cccc(Nc3nccc(n3)-c3ccccc3)c2)C11CC1
Show InChI InChI=1S/C25H22N6O2/c32-22-25(10-11-25)31(14-13-26-22)24-28-16-21(33-24)18-7-4-8-19(15-18)29-23-27-12-9-20(30-23)17-5-2-1-3-6-17/h1-9,12,15-16H,10-11,13-14H2,(H,26,32)(H,27,29,30)
PDB
MMDB

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KEGG

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PC cid
PC sid
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US Patent
n/an/a<500n/an/an/an/a7.825



AB SCIENCE

US Patent


Assay Description
SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...

US Patent US10053455 (2018)


BindingDB Entry DOI: 10.7270/Q27946PV
More data for this
Ligand-Target Pair