BDBM243355 5-{5-[3-(4-Isopropyl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-5,8- diaza-spiro[3.5]non-9- one::US10053455, 011

SMILES: CC(C)c1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CCC2)n1

InChI Key: InChIKey=CSTPTVYZUFBVNW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243355 (5-{5-[3-(4-Isopropyl- pyrimidin-2-ylamino)- phenyl...) Show SMILES CC(C)c1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CCC2)n1 Show InChI InChI=1S/C23H26N6O2/c1-15(2)18-7-10-25-21(28-18)27-17-6-3-5-16(13-17)19-14-26-22(31-19)29-12-11-24-20(30)23(29)8-4-9-23/h3,5-7,10,13-15H,4,8-9,11-12H2,1-2H3,(H,24,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
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