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SMILES: O=C1NCCN(c2ncc(o2)-c2cccc(Nc3nccc(n3)-c3cccs3)c2)C11CC1

InChI Key: InChIKey=RKKYQHICJLZWPH-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243359   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM243359
PNG
(4-{5-[3-(4-Thiophen-2- yl-pyrimidin-2-ylamino)- ph...)
Show SMILES O=C1NCCN(c2ncc(o2)-c2cccc(Nc3nccc(n3)-c3cccs3)c2)C11CC1
Show InChI InChI=1S/C23H20N6O2S/c30-20-23(7-8-23)29(11-10-24-20)22-26-14-18(31-22)15-3-1-4-16(13-15)27-21-25-9-6-17(28-21)19-5-2-12-32-19/h1-6,9,12-14H,7-8,10-11H2,(H,24,30)(H,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/a7.825



AB SCIENCE

US Patent


Assay Description
SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...

US Patent US10053455 (2018)


BindingDB Entry DOI: 10.7270/Q27946PV
More data for this
Ligand-Target Pair