BDBM243363 4-{5-[3-(4-Pyridin-3-yl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-4,7- diaza-spiro[2.5]octan-8- one::US10053455, 019

SMILES: C[N]1=C(OC(=C1)c1cccc(Nc2nccc(n2)-c2cccnc2)c1)N1CCNC(=O)C11CC1

InChI Key: InChIKey=YHQZLOQGOLBPIW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243363 (4-{5-[3-(4-Pyridin-3-yl- pyrimidin-2-ylamino)- phe...) Show SMILES C[N]1=C(OC(=C1)c1cccc(Nc2nccc(n2)-c2cccnc2)c1)N1CCNC(=O)C11CC1 |c:4,t:1,(-2.45,2.81,;-1.87,2.63,;-3.35,3.03,;-4.19,1.74,;-3.22,.54,;-1.79,1.09,;-3.62,-.94,;-5.11,-1.34,;-5.51,-2.83,;-4.42,-3.92,;-2.93,-3.52,;-1.84,-4.61,;-.35,-4.21,;.04,-2.72,;1.53,-2.33,;2.62,-3.41,;2.22,-4.9,;.73,-5.3,;3.31,-5.99,;4.64,-5.22,;5.98,-5.99,;5.98,-7.53,;4.64,-8.3,;3.31,-7.53,;-2.53,-2.03,;-3.91,4.47,;-5.43,4.71,;-5.98,6.15,;-5.01,7.34,;-3.49,7.1,;-2.52,8.3,;-2.94,5.67,;-1.74,4.7,;-1.5,6.22,)| Show InChI InChI=1S/C25H24N7O2/c1-31-16-21(34-24(31)32-13-12-27-22(33)25(32)8-9-25)17-4-2-6-19(14-17)29-23-28-11-7-20(30-23)18-5-3-10-26-15-18/h2-7,10-11,14-16H,8-9,12-13H2,1H3,(H,27,33)(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
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