null

SMILES: Cc1ccnc(Nc2cccc(C3=C[N](C)=C(O3)N3CCNC(=O)C33CC3)c2C)n1

InChI Key: InChIKey=UCBQEHAZGGJHFQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243364   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243364 (4-{5-[2-Methyl-3-(4- methyl-pyrimidin-2- ylamino)-...) Show SMILES Cc1ccnc(Nc2cccc(C3=C[N](C)=C(O3)N3CCNC(=O)C33CC3)c2C)n1 |c:15,t:12,(4.64,-7.15,;3.56,-6.06,;3.95,-4.57,;2.87,-3.48,;1.38,-3.88,;.98,-5.37,;-.51,-5.76,;-1.6,-4.68,;-3.09,-5.07,;-4.17,-3.99,;-3.78,-2.5,;-2.29,-2.1,;-1.89,-.61,;-.45,-.06,;-.53,1.48,;-1.11,1.66,;-2.02,1.88,;-2.86,.59,;-2.57,3.31,;-4.09,3.56,;-4.64,4.99,;-3.68,6.19,;-2.15,5.95,;-1.19,7.15,;-1.6,4.51,;-.41,3.54,;-.16,5.06,;-1.2,-3.19,;.29,-2.79,;2.07,-6.46,)| Show InChI InChI=1S/C22H25N6O2/c1-14-7-10-24-20(25-14)26-17-6-4-5-16(15(17)2)18-13-27(3)21(30-18)28-12-11-23-19(29)22(28)8-9-22/h4-7,10,13H,8-9,11-12H2,1-3H3,(H,23,29)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
					More data for this Ligand-Target Pair