null
SMILES: Cc1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)c1
InChI Key: InChIKey=PRLBXSIKVFRDNO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM243365 (4-{5-[3-(4-Methyl- pyridin-2-ylamino)- phenyl]oxaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AB SCIENCE US Patent | Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros... | US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV | |||||||||||
More data for this Ligand-Target Pair |