BDBM243456 US9427440, 1
SMILES: COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
InChI Key: InChIKey=UOBYJVFBFSLCTQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Genome polyprotein [1027-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,C2735L] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.20 | n/a | 0.0000760 | 3.50E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 4.40 | n/a | n/a | n/a | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | n/a | 0.0000900 | 2.00E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 5.20 | n/a | 0.000100 | 2.00E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 4.40 | n/a | 0.0000900 | 2.00E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,P2914L] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 3.80E+3 | n/a | 0.0220 | 5.90E+3 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,L2811I] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 5.50E+3 | n/a | 0.000970 | 1.80E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,P2914L] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.40E+3 | n/a | 0.0220 | 3.40E+3 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,V2913A] (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.50E+3 | n/a | 0.000840 | 5.50E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,M2833T] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 5.90 | n/a | 0.000150 | 2.60E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,M2842T] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.30 | n/a | 0.000150 | 2.50E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010,S2701T] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 3.90 | n/a | 0.000130 | 3.40E+4 | 7.4 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV)) | BDBM243456 (US9427440, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 240 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Janssen Sciences Ireland UC US Patent | Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt... | US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6 | |||||||||||
More data for this Ligand-Target Pair |