null

SMILES: ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1

InChI Key: InChIKey=CXCJVOTTZRAIPS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 24356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM24356 (N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1 Show InChI InChI=1S/C24H28BrN5O4/c25-19-7-5-6-18(14-19)22(31)16-30-21(15-26-29-30)17-10-12-20(13-11-17)27-23(32)8-3-1-2-4-9-24(33)28-34/h5-7,10-15,22,31,34H,1-4,8-9,16H2,(H,27,32)(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69.9	n/a	n/a	n/a	n/a	7.5	25
University of Illinois at Chicago					Assay Description The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...				J Med Chem 51: 3437-48 (2008) Article DOI: 10.1021/jm701606b BindingDB Entry DOI: 10.7270/Q2ZC815S
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM24356 (N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1 Show InChI InChI=1S/C24H28BrN5O4/c25-19-7-5-6-18(14-19)22(31)16-30-21(15-26-29-30)17-10-12-20(13-11-17)27-23(32)8-3-1-2-4-9-24(33)28-34/h5-7,10-15,22,31,34H,1-4,8-9,16H2,(H,27,32)(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...				J Med Chem 51: 3437-48 (2008) Article DOI: 10.1021/jm701606b BindingDB Entry DOI: 10.7270/Q2ZC815S
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM24356 (N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1 Show InChI InChI=1S/C24H28BrN5O4/c25-19-7-5-6-18(14-19)22(31)16-30-21(15-26-29-30)17-10-12-20(13-11-17)27-23(32)8-3-1-2-4-9-24(33)28-34/h5-7,10-15,22,31,34H,1-4,8-9,16H2,(H,27,32)(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...				J Med Chem 51: 3437-48 (2008) Article DOI: 10.1021/jm701606b BindingDB Entry DOI: 10.7270/Q2ZC815S
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM24356 (N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1 Show InChI InChI=1S/C24H28BrN5O4/c25-19-7-5-6-18(14-19)22(31)16-30-21(15-26-29-30)17-10-12-20(13-11-17)27-23(32)8-3-1-2-4-9-24(33)28-34/h5-7,10-15,22,31,34H,1-4,8-9,16H2,(H,27,32)(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	737	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...				J Med Chem 51: 3437-48 (2008) Article DOI: 10.1021/jm701606b BindingDB Entry DOI: 10.7270/Q2ZC815S
					More data for this Ligand-Target Pair
Polyamine deacetylase HDAC10 (Homo sapiens (Human))	BDBM24356 (N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1 Show InChI InChI=1S/C24H28BrN5O4/c25-19-7-5-6-18(14-19)22(31)16-30-21(15-26-29-30)17-10-12-20(13-11-17)27-23(32)8-3-1-2-4-9-24(33)28-34/h5-7,10-15,22,31,34H,1-4,8-9,16H2,(H,27,32)(H,28,33)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74.8	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...				J Med Chem 51: 3437-48 (2008) Article DOI: 10.1021/jm701606b BindingDB Entry DOI: 10.7270/Q2ZC815S
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM24356 (N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1 Show InChI InChI=1S/C24H28BrN5O4/c25-19-7-5-6-18(14-19)22(31)16-30-21(15-26-29-30)17-10-12-20(13-11-17)27-23(32)8-3-1-2-4-9-24(33)28-34/h5-7,10-15,22,31,34H,1-4,8-9,16H2,(H,27,32)(H,28,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15.1	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...				J Med Chem 51: 3437-48 (2008) Article DOI: 10.1021/jm701606b BindingDB Entry DOI: 10.7270/Q2ZC815S
					More data for this Ligand-Target Pair