BDBM24401 N-(naphthalen-2-yl)-5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine::Triazolopyrimidine-Based Compound, 8
SMILES: FC(F)(F)c1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
InChI Key: InChIKey=ZCCJUZIRKRMTMO-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7)) | BDBM24401 (N-(naphthalen-2-yl)-5-(trifluoromethyl)-[1,2,4]tri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 8.0 | 20 |
University of Texas Southwestern Medical Center at Dallas | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF | |||||||||||
More data for this Ligand-Target Pair |