BDBM244439 US10226449, cpd 48::US9428502, 48
SMILES: Cc1ccc(cc1-c1[nH]c(nc1Cl)C1CC1)C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N
InChI Key: InChIKey=JUENHSQLOJLIMG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty acid synthase (Homo sapiens (Human)) | BDBM244439 (US10226449, cpd 48 | US9428502, 48) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | 4 |
3-V Biosciences, Inc. US Patent | Assay Description The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS... | US Patent US9428502 (2016) BindingDB Entry DOI: 10.7270/Q20G3J23 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NS3 serine protease (NS3) (Hepatitis C Virus (Virus)) | BDBM244439 (US10226449, cpd 48 | US9428502, 48) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Conforma Therapeutics Corporation | Assay Description The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c... | J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty acid synthase (Homo sapiens (Human)) | BDBM244439 (US10226449, cpd 48 | US9428502, 48) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Conforma Therapeutics Corporation | Assay Description FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release... | J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78 | |||||||||||
More data for this Ligand-Target Pair |