BDBM24467 4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyridazin-3-yl}methyl)phenol::Triazolopyridazine, 3a
SMILES: Oc1ccc(Cc2nnc3ccc(nn23)-c2ccccc2)cc1
InChI Key: InChIKey=ZGJYGQLGSXWEMY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24467 (4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyridazin-3-yl}...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of human c-MET | Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24467 (4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyridazin-3-yl}...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Amgen | Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole... | J Med Chem 51: 2879-82 (2008) Article DOI: 10.1021/jm800043g BindingDB Entry DOI: 10.7270/Q29P2ZZ6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |