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SMILES: Oc1ccc(Cc2nnc3ncc(cn23)-c2ccccc2)cc1

InChI Key: InChIKey=PDWRZBSKQUYRCV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24468   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24468 (4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl}...) Show SMILES Oc1ccc(Cc2nnc3ncc(cn23)-c2ccccc2)cc1 Show InChI InChI=1S/C18H14N4O/c23-16-8-6-13(7-9-16)10-17-20-21-18-19-11-15(12-22(17)18)14-4-2-1-3-5-14/h1-9,11-12,23H,10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24468 (4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl}...) Show SMILES Oc1ccc(Cc2nnc3ncc(cn23)-c2ccccc2)cc1 Show InChI InChI=1S/C18H14N4O/c23-16-8-6-13(7-9-16)10-17-20-21-18-19-11-15(12-22(17)18)14-4-2-1-3-5-14/h1-9,11-12,23H,10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...				J Med Chem 51: 2879-82 (2008) Article DOI: 10.1021/jm800043g BindingDB Entry DOI: 10.7270/Q29P2ZZ6
					More data for this Ligand-Target Pair