BDBM24479 2-chloro-4-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]triazolo[4,3-a]pyridazin-6-yl)-N-methylbenzamide::Triazolopyridazine, 10i

SMILES: CNC(=O)c1ccc(cc1Cl)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2n1

InChI Key: InChIKey=QHAJMBOYAAUNDT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24479 (2-chloro-4-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl...) Show SMILES CNC(=O)c1ccc(cc1Cl)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2n1 Show InChI InChI=1S/C24H19ClN6O3/c1-26-24(32)16-5-3-14(11-18(16)25)19-7-8-22-28-29-23(31(22)30-19)13-34-21-9-10-27-20-12-15(33-2)4-6-17(20)21/h3-12H,13H2,1-2H3,(H,26,32)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...				J Med Chem 51: 2879-82 (2008) Article DOI: 10.1021/jm800043g BindingDB Entry DOI: 10.7270/Q29P2ZZ6
					More data for this Ligand-Target Pair