BDBM24514 4-nitrophenoxyphosphonic acid::4-nitrophenyl phosphate::CHEMBL24231::p-nitrophenyl phosphate
SMILES: OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O
InChI Key: InChIKey=XZKIHKMTEMTJQX-UHFFFAOYSA-N
Data: 5 IC50
PDB links: 8 PDB IDs match this monomer. 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM24514 (4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharma Curated by ChEMBL | Assay Description The compound was evaluated for its binding affinity towards phosphotyrosine binding pocket of Src protein tryrosine kinase SH2 domain | Bioorg Med Chem Lett 12: 1295-8 (2002) BindingDB Entry DOI: 10.7270/Q2959GW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM24514 (4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method | Bioorg Med Chem Lett 20: 6208-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.110 BindingDB Entry DOI: 10.7270/Q24X581T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM24514 (4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.85E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Birmingham Curated by ChEMBL | Assay Description Inhibitory activity against human serum paraoxonase (PON1) | Bioorg Med Chem Lett 13: 1623-6 (2003) BindingDB Entry DOI: 10.7270/Q23B60P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase XIII (Mus musculus (mouse)) | BDBM24514 (4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of esterase activity of mouse carbonic anhydrase 13 by CO2 hydration method | Bioorg Med Chem Lett 20: 6208-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.110 BindingDB Entry DOI: 10.7270/Q24X581T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM24514 (4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method | Bioorg Med Chem Lett 20: 6208-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.110 BindingDB Entry DOI: 10.7270/Q24X581T | |||||||||||
More data for this Ligand-Target Pair |