BDBM24632 5-chloro-7-(propan-2-ylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile::pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 11
SMILES: CC(C)Nc1cc(Cl)nc2c(cnn12)C#N
InChI Key: InChIKey=HFTLYNKTSANXFA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM24632 (5-chloro-7-(propan-2-ylamino)pyrazolo[1,5-a]pyrimi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem | DrugBank PDB Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... | J Med Chem 51: 4986-99 (2008) Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |