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SMILES: COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCCOc5c4)c3c2s1

InChI Key: InChIKey=GHNZOLKSIZOQCZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246373   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Homo sapiens (Human))	BDBM246373 (US9446044, 49) Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCCOc5c4)c3c2s1 Show InChI InChI=1S/C19H15N5O3S/c1-25-17(20)19-24-12-4-3-11-15(16(12)28-19)18(22-9-21-11)23-10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8-9,20H,6-7H2,1H3,(H,21,22,23)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.6	n/a	n/a	n/a	n/a	7.5	25
DIAXONHIT US Patent					Assay Description The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...				US Patent US9446044 (2016) BindingDB Entry DOI: 10.7270/Q2610Z7J
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM246373 (US9446044, 49) Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCCOc5c4)c3c2s1 Show InChI InChI=1S/C19H15N5O3S/c1-25-17(20)19-24-12-4-3-11-15(16(12)28-19)18(22-9-21-11)23-10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8-9,20H,6-7H2,1H3,(H,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	25
DIAXONHIT US Patent					Assay Description The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...				US Patent US9446044 (2016) BindingDB Entry DOI: 10.7270/Q2610Z7J
					More data for this Ligand-Target Pair