BDBM24696 4-aminopyrazolylpyrimidine analogue, 10b::5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(3-methoxyphenyl)methyl]pyrimidine-2,4-diamine
SMILES: COc1cccc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)c1
InChI Key: InChIKey=XSRNXUBVNYNCJC-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM24696 (4-aminopyrazolylpyrimidine analogue, 10b | 5-bromo...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 720 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra... | J Med Chem 51: 4672-84 (2008) Article DOI: 10.1021/jm800343j BindingDB Entry DOI: 10.7270/Q2RN365V | |||||||||||
More data for this Ligand-Target Pair |