BDBM24697 4-aminopyrazolylpyrimidine analogue, 10c::5-bromo-2-N-[(2-chlorophenyl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

SMILES: Clc1ccccc1CNc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1

InChI Key: InChIKey=PGFQSOQKZDCUIL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM24697 (4-aminopyrazolylpyrimidine analogue, 10c | 5-bromo...) Show SMILES Clc1ccccc1CNc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1 Show InChI InChI=1S/C17H16BrClN6/c18-12-9-21-17(20-8-11-3-1-2-4-13(11)19)23-16(12)22-15-7-14(24-25-15)10-5-6-10/h1-4,7,9-10H,5-6,8H2,(H3,20,21,22,23,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	7.4	22
AstraZeneca					Assay Description TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...				J Med Chem 51: 4672-84 (2008) Article DOI: 10.1021/jm800343j BindingDB Entry DOI: 10.7270/Q2RN365V
					More data for this Ligand-Target Pair