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BDBM24709 6,9-Diamino-2-Ethoxyacridine::7-ethoxyacridine-3,9-diamine::CHEMBL94007

SMILES: CCOc1ccc2nc3cc(N)ccc3c(N)c2c1

InChI Key: InChIKey=CIKWKGFPFXJVGW-UHFFFAOYSA-N

Data: 3 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 24709   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterases


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
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MMDB

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CHEMBL
KEGG
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PC sid
UniChem

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Article
PubMed
490 -8.52n/an/an/an/an/a7.422



University of North Carolina at Chapel Hill



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...


Chem Biol 10: 341-9 (2003)


Article DOI: 10.1016/j.chembiol.2010.07.018
BindingDB Entry DOI: 10.7270/Q2N014T9
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
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CHEMBL
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UniChem

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Article
PubMed
1.71E+4 -6.43n/an/an/an/an/a7.422



University of North Carolina at Chapel Hill



Assay Description
Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...


Chem Biol 10: 341-9 (2003)


Article DOI: 10.1016/j.chembiol.2010.07.018
BindingDB Entry DOI: 10.7270/Q2N014T9
More data for this
Ligand-Target Pair
Factor XIIa


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
PDB

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antibodypedia
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Article
PubMed
>1.00E+5>-5.40n/an/an/an/an/a7.422



University of North Carolina at Chapel Hill



Assay Description
Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...


Chem Biol 10: 341-9 (2003)


Article DOI: 10.1016/j.chembiol.2010.07.018
BindingDB Entry DOI: 10.7270/Q2N014T9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
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PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



University of Missouri

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against telomerase (Compound released from DNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3)


Bioorg Med Chem Lett 11: 2727-30 (2001)


BindingDB Entry DOI: 10.7270/Q2PN94XJ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
PDB

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CHEMBL
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PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



University of Missouri

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against telomerase (Compound released from underivatized resin


Bioorg Med Chem Lett 11: 2727-30 (2001)


BindingDB Entry DOI: 10.7270/Q2PN94XJ
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
UniProtKB/SwissProt

antibodypedia
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CHEMBL
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 4.35E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranes


Drug Metab Dispos 40: 2332-41 (2012)


Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM24709
PNG
(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Show SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Show InChI InChI=1S/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)
PDB

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CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



University of Missouri

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against telomerase (Compound released from underivatized resin


Bioorg Med Chem Lett 11: 2727-30 (2001)


BindingDB Entry DOI: 10.7270/Q2PN94XJ
More data for this
Ligand-Target Pair