BDBM24714 5-methyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]hexadeca-1(9),2,5,10,12,14-hexaene::Tetrahydropyrazolo[3,4-a]carbazole, 22
SMILES: Cc1[nH]nc-2c1CCc1c-2[nH]c2ccccc12
InChI Key: InChIKey=HIJHIBWSHVXXGO-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aurora kinase B (Homo sapiens (Human)) | BDBM24714 (5-methyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Genentech | Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the... | J Med Chem 51: 4465-75 (2008) Article DOI: 10.1021/jm800052b BindingDB Entry DOI: 10.7270/Q2H70D4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase A (Homo sapiens (Human)) | BDBM24714 (5-methyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Genentech | Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the... | J Med Chem 51: 4465-75 (2008) Article DOI: 10.1021/jm800052b BindingDB Entry DOI: 10.7270/Q2H70D4F | |||||||||||
More data for this Ligand-Target Pair |