BDBM24719 13-methyl-8,11,12-triazatetracyclo[7.6.0.0^{2,7}.0^{10,14}]pentadeca-1(9),2,4,6,10,13-hexaene::dihydropyrazolocyclopentaindole, 21

SMILES: Cc1[nH]nc-2c1Cc1c-2[nH]c2ccccc12

InChI Key: InChIKey=JHGGFQICWDUZTH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24719   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM24719 (13-methyl-8,11,12-triazatetracyclo[7.6.0.0^{2,7}.0...) Show SMILES Cc1[nH]nc-2c1Cc1c-2[nH]c2ccccc12 Show InChI InChI=1S/C13H11N3/c1-7-9-6-10-8-4-2-3-5-11(8)14-12(10)13(9)16-15-7/h2-5,14H,6H2,1H3,(H,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	7.5	22
Genentech					Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...				J Med Chem 51: 4465-75 (2008) Article DOI: 10.1021/jm800052b BindingDB Entry DOI: 10.7270/Q2H70D4F
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM24719 (13-methyl-8,11,12-triazatetracyclo[7.6.0.0^{2,7}.0...) Show SMILES Cc1[nH]nc-2c1Cc1c-2[nH]c2ccccc12 Show InChI InChI=1S/C13H11N3/c1-7-9-6-10-8-4-2-3-5-11(8)14-12(10)13(9)16-15-7/h2-5,14H,6H2,1H3,(H,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	7.5	22
Genentech					Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...				J Med Chem 51: 4465-75 (2008) Article DOI: 10.1021/jm800052b BindingDB Entry DOI: 10.7270/Q2H70D4F
					More data for this Ligand-Target Pair