BDBM24755 2-benzyl-5-[4-({7-[3-(4-ethylpiperazin-1-yl)propoxy]-6-methoxyquinolin-4-yl}oxy)-3-fluorophenyl]-3-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 26

SMILES: CCN1CCN(CCCOc2cc3nccc(Oc4ccc(cc4F)-c4cnc(Cc5ccccc5)n(C)c4=O)c3cc2OC)CC1

InChI Key: InChIKey=BJLCYGZYAODRFD-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24755   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24755 (2-benzyl-5-[4-({7-[3-(4-ethylpiperazin-1-yl)propox...) Show SMILES CCN1CCN(CCCOc2cc3nccc(Oc4ccc(cc4F)-c4cnc(Cc5ccccc5)n(C)c4=O)c3cc2OC)CC1 Show InChI InChI=1S/C37H40FN5O4/c1-4-42-16-18-43(19-17-42)15-8-20-46-35-24-31-28(23-34(35)45-3)32(13-14-39-31)47-33-12-11-27(22-30(33)38)29-25-40-36(41(2)37(29)44)21-26-9-6-5-7-10-26/h5-7,9-14,22-25H,4,8,15-21H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	21	-10.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24755 (2-benzyl-5-[4-({7-[3-(4-ethylpiperazin-1-yl)propox...) Show SMILES CCN1CCN(CCCOc2cc3nccc(Oc4ccc(cc4F)-c4cnc(Cc5ccccc5)n(C)c4=O)c3cc2OC)CC1 Show InChI InChI=1S/C37H40FN5O4/c1-4-42-16-18-43(19-17-42)15-8-20-46-35-24-31-28(23-34(35)45-3)32(13-14-39-31)47-33-12-11-27(22-30(33)38)29-25-40-36(41(2)37(29)44)21-26-9-6-5-7-10-26/h5-7,9-14,22-25H,4,8,15-21H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair