BDBM247567 US10112931, Example 133::US9434719, 133::US9688672, Example 133
SMILES: C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F
InChI Key: InChIKey=GBGXXLPKYDLGDN-MVHXDWSJSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
NOVARTIS AG US Patent | Assay Description The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph... | US Patent US9434719 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 25 |
NOVARTIS AG US Patent | Assay Description The biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction ... | US Patent US9434719 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 956 | n/a | n/a | n/a | n/a | 7.5 | 25 |
NOVARTIS AG US Patent | Assay Description The IDH1 (R132H) mutant catalyzes the reduced form of NADP+(NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide pho... | US Patent US9688672 (2017) BindingDB Entry DOI: 10.7270/Q2251GBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
NOVARTIS AG US Patent | Assay Description Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc... | US Patent US10112931 (2018) BindingDB Entry DOI: 10.7270/Q2PG1TRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 956 | n/a | n/a | n/a | n/a | 7.5 | 25 |
NOVARTIS AG US Patent | Assay Description The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph... | US Patent US10112931 (2018) BindingDB Entry DOI: 10.7270/Q2PG1TRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
NOVARTIS AG US Patent | Assay Description Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc... | US Patent US10112931 (2018) BindingDB Entry DOI: 10.7270/Q2PG1TRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
NOVARTIS AG US Patent | Assay Description The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph... | US Patent US10112931 (2018) BindingDB Entry DOI: 10.7270/Q2PG1TRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM247567 (US10112931, Example 133 | US9434719, 133 | US96886...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
NOVARTIS AG US Patent | Assay Description The IDH1 (R132H) mutant catalyzes the reduced form of NADP+(NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide pho... | US Patent US9688672 (2017) BindingDB Entry DOI: 10.7270/Q2251GBM | |||||||||||
More data for this Ligand-Target Pair |